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Increased CSF C4d in demyelinating neuropathy indicates the radicular involvement
Y Koguchi1, T Yamada, S Kuwabara
1Department of Neurology, School of Medicine, Chiba University, Japan.
Acta Neurologica Scandinavica
|January 1, 1995
Abstract:
Plasma and cerebrospinal fluid (CSF) levels of C4d and the circulating immune complex (CIC) to C1q were measured in 12 patients with chronic inflammatory demyelinating polyneuropathy and Guillain-Barré syndrome. CSF C4d values more than 2 SD from the mean of 8 cervical spongylosis cases were demonstrated in the patients with proximal demyelination. The CSF C4d probably originated from both intrathecal synthesis and the systemic circulation. CSF levels of C4d may serve as a sensitive indicator for the radicular involvement in demyelinating polyneuropathy.