Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chaparral-induced hepatic injury

W B Batchelor1, J Heathcote, I R Wanless

  • 1Department of Medicine, Toronto Hospital, University of Toronto, Canada.

The American Journal of Gastroenterology
|May 1, 1995
PubMed
Summary

Chaparral leaf ingestion can cause liver injury (hepatotoxicity) in some individuals. Discontinuing the herb led to recovery in two reported cases, highlighting potential risks of herbal remedies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathway-based analysis of primary biliary cirrhosis genome-wide association studies.

Genes and immunity·2013
Same author

Immigrant patients with chronic hepatitis C and advanced fibrosis have a higher risk of hepatocellular carcinoma.

Journal of viral hepatitis·2012
Same author

World Gastroenterology Organisation Guideline. Hepatocellular carcinoma (HCC): a global perspective.

Journal of gastrointestinal and liver diseases : JGLD·2010
Same author

Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update.

Journal of hepatology·2007
Same author

Gene expression profiling of acute liver stress during living donor liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
Same author

Treating chronic hepatitis C with pegylated interferon alfa-2a (40 KD) and ribavirin in clinical practice.

Alimentary pharmacology & therapeutics·2006

Area of Science:

  • Hepatology
  • Toxicology
  • Integrative Medicine

Background:

  • Chaparral (Larrea tridentata) is a desert shrub used in traditional medicine.
  • Concerns exist regarding the safety of herbal supplements, particularly their potential for liver damage.

Observation:

  • Two patients developed biopsy-proven hepatitis after consuming chaparral leaf.
  • Symptoms appeared within 2-3 months of daily ingestion.
  • One patient experienced a recurrence of hepatitis upon re-exposure to chaparral.

Findings:

  • Chaparral leaf ingestion is associated with drug-induced liver injury.
  • Hepatotoxicity resolved after cessation of chaparral use.
  • Rechallenge confirmed the causal relationship between chaparral and hepatitis.

Implications:

  • Healthcare providers should inquire about herbal supplement use in patients with unexplained hepatitis.
  • Increased awareness of chaparral's potential hepatotoxicity is crucial for public health.
  • Non-prescription herbal remedies require careful consideration due to potential adverse effects.

Related Experiment Videos