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Related Experiment Videos

Effect of peptide YY on human renal function

R J Playford1, S Mehta, P Upton

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.

The American Journal of Physiology
|April 1, 1995
PubMed
Summary

Peptide YY (PYY) influences kidney function after meals. This study shows PYY reduces filtration rate and increases sodium excretion, suggesting PYY agonists may treat sodium overload.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Gastroenterology

Background:

  • Peptide YY (PYY) is an intestinal hormone released post-meal.
  • PYY/neuropeptide Y (NPY) receptors are present in the human kidney.
  • The role of PYY in renal function is not fully understood.

Purpose of the Study:

  • To investigate the effects of exogenous Peptide YY (PYY) on human renal function.
  • To determine if PYY influences glomerular filtration rate, renal plasma flow, and sodium excretion.
  • To explore the potential therapeutic implications of PYY modulation in conditions of sodium imbalance.

Main Methods:

  • Intravenous infusion of PYY at two doses (0.4 and 1.2 pmol.kg-1.min-1) in healthy male subjects.
  • Measurement of glomerular filtration rate, plasma renin activity, aldosterone levels, and renal plasma flow.

Related Experiment Videos

  • Collection of urine to assess sodium excretion before, during, and after PYY infusion.

    • Main Results:

    • PYY infusion at physiological postprandial levels significantly decreased glomerular filtration rate (10%) and plasma renin activity (30%).
    • PYY increased sodium excretion by approximately 30% and reduced aldosterone levels.
    • Higher PYY doses, mimicking diarrheal illness, caused similar effects and reduced renal plasma flow by 10%.

    Conclusions:

    • PYY plays a significant role in regulating postprandial renal function, including natriuresis.
    • PYY may be a key mediator of the body's response to dietary sodium intake.
    • PYY agonists represent a potential therapeutic strategy for managing conditions characterized by sodium overload.