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Circulating tumor necrosis factor-alpha does not mediate endotoxin-induced hypothermia in rats
K Schotanus1, G M Holtkamp, N van Rooijen
1Research Institute Neurosciences, Vrije Universiteit, Faculty of Medicine, Amsterdam, The Netherlands.
The American Journal of Physiology
|April 1, 1995
Summary
Eliminating macrophages abolished endotoxin-induced hypothermia and tumor necrosis factor-alpha (TNF-alpha) increases in rats. Circulating TNF-alpha is not the cause of hypothermia, suggesting complex immune responses.
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