Ocular cicatricial pemphigoid associated with practolol therapy

Area of Science:

• Ophthalmology
• Dermatology
• Immunology

Background:

• Cicatricial pemphigoid (CP) is a rare, chronic autoimmune blistering disease primarily affecting mucous membranes, particularly the eyes.
• Ocular involvement in CP can lead to severe morbidity, including vision loss.

Observation:

• This report details a case of severe cicatricial blistering affecting the ocular mucous membrane.
• The patient presented with clinical manifestations consistent with significant ocular surface damage.

Findings:

• Laboratory and clinical findings in this case were directly comparable to established criteria for cicatricial pemphigoid.
• Histopathological and immunofluorescence studies supported the diagnosis, showing characteristic patterns of autoimmune blistering.

Implications:

• This case reinforces the importance of recognizing ocular mucous membrane pemphigoid in patients with severe cicatricial conjunctivitis.
• Early diagnosis and appropriate management are crucial to prevent irreversible vision impairment.
• Further research into the pathogenesis and treatment of ocular CP is warranted.