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THC-induced place and taste aversions in Lewis and Sprague-Dawley rats
1Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Behavioral Neuroscience
|February 1, 1995
Abstract:
The hedonic properties of delta-9-tetrahydrocannabinol (THC) were assessed in place and taste conditioning paradigms in both Lewis and Sprague-Dawley rat strains. THC produced place avoidance, taste avoidance, and aversive taste reactivity responses in both strains. The Lewis strain displayed more aversive taste reactions and a stronger taste avoidance when conditioned with lower doses of THC than did the Sprague-Dawley strain of rats. THC is an anomalous drug of abuse that appears to be aversive to rats when assessed by these measures.