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Nocardia asteroides keratitis. A case report

R A Ralph, M A Lemp, G Liss

    The British Journal of Ophthalmology
    |February 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    A rare Nocardia asteroides infection caused a persistent corneal ulcer in a child. Prompt addition of penicillin G drops was crucial for complete healing after initial treatments failed.

    Area of Science:

    • Ophthalmology
    • Microbiology
    • Infectious Diseases

    Background:

    • Corneal ulcers can lead to vision loss if not treated promptly.
    • Bacterial and fungal infections are common causes of corneal ulcers, especially after trauma.

    Observation:

    • An 11-year-old girl presented with a corneal ulcer following a fishline sinker abrasion.
    • Initial treatment with topical antibiotics and steroids failed to resolve stromal opacities.
    • Microscopic examination revealed branching hyphae, identified as Nocardia asteroides via culture.

    Findings:

    • Nocardia asteroides keratitis presented as a ring-like stromal opacity.
    • Standard treatments were partially effective, but complete resolution required additional penicillin G.
    • This case highlights the challenges in treating Nocardia keratitis.

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    Implications:

    • Nocardia asteroides should be considered in the differential diagnosis of persistent microbial keratitis, particularly after ocular trauma.
    • Aggressive and tailored antimicrobial therapy, including penicillin G, may be necessary for successful treatment.
    • Early microbiological diagnosis and appropriate treatment are vital to prevent long-term visual impairment.