[Development of immune tolerance to microbial and cross-reacting tissue antigens in mice]

C. albicans vaccine was administered to newborn mice (CC57BR). A tolerance to the microbial antigen was thus obtained which depressed the reaction of rejection of the C3H mice skin allograft. Tolerant mice displayed a reduction of the number of lymphoid cells reacting with the microbial and tissue antigen of the donor in the reactions of immunoadhesion and blasttransformation; there was also seen a reduction of the cytotoxic activity to the fibroblasts of C3H mice. The tolerance to the microbial and cross reacting transplantation antigens was pased by the spleen cells to syngenous recipients irradiated in a dose of 700 R.