[Modern representations of multiple forms of cyclic nucleotide phosphodiesterases in mammalian tissues]

The literary data from the past 10-15 years concerning cyclic nucleotide phosphodiesterase from animal tissues have been reviewed. The major properties of multiple forms of the enzyme differing in the mode of regulation, substrate specificity, physico-chemical parameters and primary structure are compared. The possible physiological role of the main phosphodiesterase forms and ways of their pharmacological regulation are discussed.