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Cardiac autonomic function in obese patients

P Valensi1, B N Thi, B Lormeau

  • 1Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean Verdier, Bondy, France.

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|February 1, 1995
PubMed
Summary

Cardiac autonomic dysfunction is common in obese, non-diabetic individuals. This dysfunction may contribute to the poor cardiovascular outlook associated with obesity, impacting heart rate and blood pressure regulation.

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Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Obesity Medicine

Background:

  • Obesity is linked to increased cardiovascular risk.
  • Cardiac autonomic function plays a crucial role in cardiovascular health.
  • Understanding autonomic dysfunction in obesity is vital for risk stratification.

Purpose of the Study:

  • To investigate the prevalence of cardiac autonomic dysfunction in obese, non-diabetic subjects.
  • To assess the relationship between autonomic function and obesity parameters.
  • To explore the clinical implications of autonomic dysfunction in this population.

Main Methods:

  • A cohort of 121 obese, non-diabetic individuals and 40 healthy controls was studied.
  • Standardized autonomic function tests assessing parasympathetic (Valsalva, deep breathing, lying-to-standing) and sympathetic (standing, handgrip) control were performed.

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  • Age-adjusted analysis was used to evaluate test results.

    • Main Results:

    • 40.5% of obese subjects exhibited abnormalities in at least one parasympathetic test.
    • Abnormalities in sympathetic function (handgrip test) were observed in a smaller subset.
    • No significant correlation was found between autonomic test results and sex or body mass index.

    Conclusions:

    • Cardiac autonomic dysfunction is prevalent in obese, non-diabetic individuals, detectable through simple tests.
    • This dysfunction may contribute to the adverse cardiovascular prognosis associated with obesity.
    • Further research is needed to determine if autonomic dysfunction is a complication or a marker of specific obesity subtypes.