Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune response to an allogeneic progressively growing solid tumor

A E Eggers

    Cancer Research
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A chronic dysfunctional stress response can cause stroke by stimulating platelet activation, migraine, and hypertension.

    Medical hypotheses·2005
    Same author

    Neurological theory of hypertension.

    Medical hypotheses·2003
    Same author

    New neural theory of migraine.

    Medical hypotheses·2001
    Same author

    Antiglioma cytotoxic immune response.

    Journal of neurosurgery·1994
    Same author

    Intralymphatic immunotherapy of glioblastoma.

    New York state journal of medicine·1992
    Same author

    Induction of anti-idiotypic antibodies to a myeloma protein linked covalently to muramyl dipeptide.

    Journal of immunological methods·1990
    Same journal

    CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

    Cancer research·2026
    Same journal

    A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

    Cancer research·2026
    Same journal

    Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

    Cancer research·2026
    Same journal

    Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

    Cancer research·2026
    Same journal

    Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

    Cancer research·2026
    Same journal

    Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

    Cancer research·2026
    See all related articles

    BALB/c mice with growing tumors fail to mount an effective cytotoxic lymphocyte response against tumor histocompatibility antigens. This immune deficiency involves both sensitization and effector stages, not serum factors or suppressor cells.

    Area of Science:

    • Immunology
    • Cancer Biology

    Background:

    • Methylcholanthrene-induced tumors in mice can evade host immune responses.
    • Understanding immune evasion mechanisms is crucial for cancer therapy.

    Purpose of the Study:

    • To investigate the defects in the host cytotoxic lymphocyte response against a progressively growing tumor in BALB/c mice.
    • To determine if serum factors or suppressor cells contribute to the immune evasion.

    Main Methods:

    • Utilized a C57BL/6 (B6) methylcholanthrene-induced solid tumor model in BALB/c mice.
    • Assessed cytotoxic lymphocyte activity using 51Cr release assays with cultured and fresh tumor cells.
    • Evaluated the role of serum factors and suppressor cells in the immune response.

    Main Results:

    Related Experiment Videos

    • BALB/c mice with growing B6 tumors failed to generate cytotoxic lymphocytes against tumor histocompatibility (H-) antigens.
    • Tumor cells were effective targets in 51Cr release assays but poor immunogens for in vitro immunization.
    • Skin graft rejection occurred normally and did not affect tumor growth.

    Conclusions:

    • The host cytotoxic lymphocyte response against the tumor exhibits defects in both sensitization and effector phases.
    • These defects likely do not involve serum factors or suppressor cells, suggesting intrinsic tumor-related immune resistance.