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[Peanut sensitization and oily solution vitamin preparations]
G de Montis1, M Truong, B Toussaint
1Hôpital de jour, service PB, Paris, France.
Insights
Vitamin D preparations containing groundnut oil significantly increase the risk of peanut sensitization in infants. Researchers recommend excluding groundnut oil from all infant foods and medications to prevent early allergy development.
Area of Science:
- Pediatric Allergy
- Immunology
- Nutritional Science
Background:
- Early sensitization to peanut allergens can occur via infant nutrition.
- Investigating the link between early feeding practices and peanut sensitization is crucial.
Purpose of the Study:
- To systematically assess the relationship between early feeding and peanut sensitization in infants.
- To identify specific food or drug components that may increase allergy risk.
Main Methods:
- 102 children aged 4-35 months, referred for non-peanut allergy symptoms, were tested.
- Skin prick tests were used to determine sensitization to peanut allergens.
- Infant feeding histories, including milk formulas and vitamin D preparations, were analyzed.
Main Results:
- 19% of children showed positive peanut sensitization.
- Breastfeeding and standard milk formulas did not affect sensitization rates.
- Vitamin D preparations containing groundnut oil significantly increased peanut sensitization risk (p < 0.008), with odds ratios up to 8.25.
Conclusions:
- Groundnut oil in vitamin D preparations is a significant risk factor for peanut sensitization in infants.
- Excluding groundnut oil from infant foods and medications is recommended.
- This finding supports current guidelines for hypoallergenic infant formulas.
Background And Methods:
Early sensitization to peanut can occur through milk formulas which contain peanut oil. Thus, the groundnut allergens in relation to the early feeding have been systematically tested in all children referred to the paediatric allergy unit for symptoms not related to peanut allergy.
Results:
Out of 102 children, 4 to 35 months old, 19 had a positive test (weal > 3 mm). Neither breast feeding nor milk formulas changed the frequency of sensitization. On the contrary, vitamin D preparations in groundnut oil significantly increased the risk (p < 0.008). Odds ratios were 5.47 in the case of neonatal prescription, 4.82 in case of delayed prescription. Odds ratio increased to 8.25 (p < 0.04) in allergic children under two years who had received oily vitamin D preparation during their neonatal period.
Conclusions:
The result suggest to leave groundnut oil out of all foods and drugs given to infants and young children, as required for infantile milk formulas.