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Updated: Jul 23, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Empty bladder and dehydrated pelvic patch water uptake in Bufo marinus: inhibition by captopril
V McDevitt1, A Kenedy, R H Parsons
1Department of Biology and Biophysics Center, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.
Abstract:
Dehydration (10.3 +/- 2.2%, N = 7) caused a significant increase in pelvic patch water uptake (Jv) from 875 +/- 86 (N = 21) to 2130 +/- 150 (N = 21) cm3.cm-2 x 10(-7), while the pectoral Jv increased from 258 +/- 31 (N = 21) to 545 +/- 75 (N = 21 cm3.cm-2 x 10(-7). Captopril inhibited the pelvic patch Jv in empty bladder toads decreasing the Jv from 978 +/- 45 (N = 27) to 607 +/- 38 (N = 27) cm3.cm-2 x 10(-7). In dehydrated toads (15 +/- 2%, N = 14), captopril reduced the pelvic patch Jv from 1807 +/- 213 (N = 21) to 957 +/- 91 (N = 21) cm3.cm-2 x 10(-7). Captopril injection decreased the blood pressure in dehydrated toads from 25.6 +/- 1.9 (N = 21) to 16.9 +/- 1.5 (N = 21) mmHg with no change in heart rate.
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