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Additional assignment of the human 5S rRNA genes to chromosome region 1q31
B Lomholt1, S Frederiksen, J N Nielsen
1Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark.
Cytogenetics and Cell Genetics
|January 1, 1995
Abstract:
A major fraction of the human 5S rRNA genes has previously been assigned to chromosome region 1q42.11-->q42.13 (Sørensen et al., 1991). Through in situ hybridization of different tritiated probes to metaphase spreads, we have demonstrated that a minor fraction of the 5S rRNA genes is localized at band 1q31. This fraction amounts to 25-30% of the genes found in the region 1q42.11-->q42.13. Results obtained with the chromosomes of a balanced translocation carrier involving this region indicate that the major cluster is localized in band 1q42.13.