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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
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Pleural involvement in HIV infection: clinico-radiological profile and prognostic significance

V K Arora1, K Gowrinath, R S Rao

  • 1Department of Tuberculosis and Chest Diseases, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.

The Indian Journal of Chest Diseases & Allied Sciences
|July 1, 1994
PubMed

Insights

Pleural involvement in patients with human immunodeficiency virus (HIV) infection is often on the right side. These HIV-positive patients with pleural disease face a high mortality rate, suggesting a poor prognosis.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Oncology

Background:

  • Pleural involvement is a significant complication in patients with human immunodeficiency virus (HIV) infection.
  • Understanding the clinico-radiological characteristics and etiological spectrum is crucial for managing these complex cases.

Purpose of the Study:

  • To describe the clinico-radiological profile of patients with HIV and pleural involvement.
  • To identify the common causes and outcomes of pleural effusions in this population.

Main Methods:

  • Retrospective analysis of seven patients with HIV infection and pleural involvement.
  • Review of clinical data, radiological findings, and pleural biopsy results.

Main Results:

  • Five out of seven patients presented with right-sided pleural effusion.
  • Etiologies identified through pleural biopsy included tuberculosis (2 cases) and invasive candidiasis (1 case).
  • A high mortality rate of 5/7 (71.4%) was observed.

Conclusions:

  • Pleural involvement in HIV-infected individuals is associated with significant morbidity and mortality.
  • Tuberculosis and invasive fungal infections are important etiological considerations.
  • Prompt diagnosis and management are critical, though prognosis remains poor.

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