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A noninvasive computerized tail-cuff system for measuring blood pressure in mice
J H Krege1, J B Hodgin, J R Hagaman
1Department of Pathology, University of North Carolina at Chapel Hill 27599, USA.
Hypertension (Dallas, Tex. : 1979)
|May 1, 1995
Summary
A new computerized tail-cuff system accurately measures mouse blood pressure noninvasively. This validated system shows high correlation with invasive methods, offering reproducible results for cardiovascular research.
Area of Science:
- Physiology
- Pharmacology
- Biomedical Engineering
Background:
- Accurate blood pressure measurement in mice is crucial for cardiovascular research.
- Existing methods can be invasive or lack automation.
- A validated, noninvasive system is needed for reliable data collection.
Purpose of the Study:
- To validate a novel, automated, noninvasive computerized tail-cuff system for mouse blood pressure measurement.
- To assess the system's reproducibility and correlation with invasive methods.
Main Methods:
- Mice were treated with enalapril or NG-nitro-L-arginine methyl ester to induce a range of blood pressures.
- Automated tail-cuff system used for blood pressure and pulse rate measurements.
- Comparison with intra-arterial blood pressure measurements in unrestrained, unanesthetized mice.
Main Results:
- The automated tail-cuff system demonstrated reproducible blood pressure measurements over time.
- Tail-cuff and intra-arterial blood pressure measurements were highly correlated (r = .86 for individuals, r = .98 for group means).
- The system successfully captured blood pressure variations induced by pharmacological agents.
Conclusions:
- The computerized tail-cuff system provides a validated, noninvasive, and reproducible method for measuring mouse blood pressure.
- This system is a reliable tool for cardiovascular research, correlating well with invasive techniques.
- The automation and accuracy make it suitable for drug efficacy studies and physiological monitoring.