Photodynamic action increases leakage of the mitochondrial electron transport chain

Rat liver submitochondrial particles were treated with rose bengal or flavin mononucleotide and irradiated with visible or near UV light. In both cases, oxygen consumption is impaired after irradiation while O2-. production increases significantly. This suggests that exogenous or endogenous photosensitizers can induce more electron leakage in the mitochondrial respiratory chain. Photobiological implications in dermatology are discussed.