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Related Experiment Videos

A desperate solution: individual autonomy and the double-blind controlled experiment

G Logue1, S Wear

  • 1Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.

The Journal of Medicine and Philosophy
|February 1, 1995
PubMed
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The Journal of clinical ethics·1995

Randomization in clinical trials may exploit desperate patients. An alternative proposes enrolling "desperate volunteers" in active treatment arms, but this is critiqued for hindering medical progress and misinterpreting patient autonomy.

Area of Science:

  • Clinical Trials
  • Medical Ethics
  • Patient Autonomy

Background:

  • Double-blind controlled experiments utilize randomization.
  • This randomization may conflict with the autonomy of patients seeking urgent cures.
  • The ethical implications of patient desperation in clinical trials require examination.

Purpose of the Study:

  • To evaluate the ethical objections to randomization for patients in desperate need of a cure.
  • To present and critique a proposal for modifying randomization procedures for "desperate volunteers" in clinical trials.

Main Methods:

  • Literature review and ethical analysis of existing clinical trial randomization practices.
  • Critique of the proposal by Minogue et al. regarding "desperate volunteers".
Keywords:
Analytical ApproachBiomedical and Behavioral Research

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Main Results:

  • The proposal to enroll "desperate volunteers" in active arms is presented.
  • This proposal is critiqued for potentially hindering medical progress.
  • The critique also highlights concerns about clinical response and the feasibility of patient autonomy in such contexts.

Conclusions:

  • The ethical dilemma of randomization for desperate patients remains complex.
  • Modifying randomization for "desperate volunteers" faces significant ethical and practical challenges.
  • Balancing patient autonomy with the need for rigorous scientific advancement in clinical trials is crucial.