Effect of thyroxine on the development of somatosensory and visual evoked potentials in the rat

The thyroid hormone thyroxine (T4), administered post-natally to neonatal rats, has been shown to accelerate development of auditory function, as expressed by auditory nerve-brainstem evoked responses. This study investigated whether this earlier development was also reflected in other sensory modalities. Rat pups were injected with T4 from the day of birth for 10 consecutive days. Somatosensory evoked potentials, both from the cortex and from sub-cortical structures, and flash-elicited visual evoked potentials (VEP), were recorded at various ages up to 3 months. The recordings were compared with those from control rats from the same litters. Only a minimal difference was found between the experimental and control groups, the most significant being in the VEP at age 12 days, by which time the eyes of most of the experimental rats had opened, which was not the case for the majority of control rats. This difference disappeared with eye-opening in the control rats. Although T4 is known to affect myelinization and synaptic transmission in developing rat brain, this apparently only minimally affects the functioning of the brain as expressed by evoked potentials, both in the short and long term. The main effect of neonatal hyperthyroidism in these rats appeared to be accelerated development of the end organ (the eye and the ear).