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Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: the case for aggressive
K W van Besien1, I F Khouri, S A Giralt
1Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Purpose:
To evaluate the role of allogeneic bone marrow transplantation (BMT) in recurrent low-grade lymphoma.
Patients And Methods:
Between 1989 and 1994, 10 patients with chemotherapy-refractory and recurrent low-grade lymphoma were treated with myeloablative therapy and allogeneic BMT. All patients had poor prognostic features and had been extensively pretreated.
Results:
Eight patients achieved a complete remission and none have relapsed at a median follow-up time of 816 days (range, 346 to 1,865). Two patients died of early complications. The actuarial survival and failure-free survival rates are both 80% +/- 12.6%. For surviving patients, the duration of the current remission exceeds that of any previous remission achieved.
Conclusion:
These results compare favorably with those for autologous BMT. Allogeneic BMT offers considerable promise for the treatment of patients with poor-prognosis low-grade lymphoma. Its role should be further defined in prospective studies.