[The efficacy of midazolam-famotidine suppository for premedication in children]

Area of Science:

• Pediatric Anesthesiology
• Pharmacology
• Gastroenterology

Background:

• Premedication in pediatric surgery aims to reduce anxiety and optimize gastric conditions.
• Current premedication strategies may have variable effects on gastric volume and pH.
• Ensuring adequate gastric pH and minimal volume is crucial for patient safety during anesthesia.

Purpose of the Study:

• To evaluate the efficacy of a midazolam-famotidine suppository (M-F suppository) as a premedicant in pediatric patients.
• To compare the effects of the M-F suppository with intramuscular hydroxyzine on gastric parameters.
• To assess the sedative efficacy of the M-F suppository.

Main Methods:

• A prospective study involving pediatric patients (5 months to 7 years) scheduled for minor elective surgery.
• Patients received either an M-F suppository (midazolam 0.5 mg/kg and famotidine 2 mg/kg) or an intramuscular injection of hydroxyzine (1 mg/kg).
• Gastric pH and volume were measured in both groups.

Main Results:

• The M-F suppository group exhibited significantly higher gastric pH (3.90 ± 0.34) compared to the intramuscular injection group (1.82 ± 0.15).
• Gastric volume was significantly lower in the M-F suppository group (1.88 ± 0.54 ml) than in the intramuscular injection group (8.42 ± 1.76 ml).
• The M-F suppository demonstrated comparable sedative effects to intramuscular hydroxyzine.

Conclusions:

• The midazolam-famotidine suppository is an effective premedicant for pediatric patients.
• The M-F suppository favorably alters gastric parameters, potentially improving safety during anesthesia.
• This formulation presents a viable alternative to traditional intramuscular premedication in pediatric surgical settings.