Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvascular dysfunction after myocardial ischemia

R J Dignan1, M Kadletz, C M Dyke

  • 1Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

The Journal of Thoracic and Cardiovascular Surgery
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the role of executive function in brain responses to infant crying among new parents.

Social cognitive and affective neuroscience·2026
Same author

Synthetic and living micropropellers for convection-enhanced nanoparticle transport.

Science advances·2019
Same author

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

Chemical communications (Cambridge, England)·2015
Same author

Right superior vena cava draining predominantly into the left atrium causing cyanosis in a young child.

Pediatric cardiology·2003
Same author

A model of BAX gene delivery to human lung cancer.

Anticancer research·2002
Same author

Penetrating injury to the heart requiring cardiopulmonary bypass: a case study.

The journal of extra-corporeal technology·2002
Same journal

Bridging Pediatric and Young Adult Cancer Survivorship: Defining the Thoracic Surgeon's Role Across the Continuum.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Beyond compensatory expansion: Extending 3-dimensional computed tomography volumetry toward lung-preserving local therapy.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

A CALL FOR STANDARDIZATION OF HYBRID ARCH FROZEN ELEPHANT TRUNK OUTCOMES REPORTING.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Pediatric Mitral Valve Surgery: Current Practice from the European Congenital Heart Surgeons Association Congenital Database Analysis.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Rethinking Failure to Rescue in Cardiac Surgery.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Undersized Fontan conduits are not without risk.

The Journal of thoracic and cardiovascular surgery·2026
See all related articles

Small intramyocardial arteries show early endothelial dysfunction during global ischemia, unlike larger coronary arteries. This microvascular injury may contribute to reperfusion issues.

Area of Science:

  • Cardiovascular Physiology
  • Ischemic Pathophysiology
  • Vascular Biology

Background:

  • Large coronary arteries demonstrate resistance to prolonged global ischemia.
  • Previous studies focused less on the functional response of small intramyocardial arteries to ischemia.

Purpose of the Study:

  • To test the hypothesis that small intramyocardial artery endothelium and smooth muscle are more sensitive to ischemic injury than large artery counterparts.
  • To evaluate the functional changes in intramyocardial arteries during varying durations of global ischemia.

Main Methods:

  • Utilized a small-vessel myograph to assess porcine coronary artery segments.
  • Induced normothermic global ischemia in porcine hearts for up to 120 minutes.
  • Measured potassium-induced smooth muscle contraction, bradykinin-mediated relaxation, and sodium nitroprusside-mediated relaxation.

Related Experiment Videos

Main Results:

  • Endothelium-mediated relaxation in small arteries was significantly impaired after 60 minutes of ischemia.
  • Smooth muscle contraction and direct relaxation were also reduced, but at later time points (90-120 minutes).
  • Compared to epicardial arteries, intramyocardial arteries showed earlier and more pronounced endothelial dysfunction.

Conclusions:

  • Intramyocardial arterial endothelium is highly sensitive to global ischemic injury.
  • Early endothelial cell injury in microvasculature contributes to ischemia-induced dysfunction.
  • Microvascular endothelial dysfunction may play a role in the no-reflow phenomenon during reperfusion injury.