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Updated: Aug 15, 2026

Assessment of Sexual Behavior of Male Mice
Published on: March 5, 2020
Linkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice
S Tordjman1, P L Roubertoux, M Carlier
1URA CNRS 1294, Université Paris V-René Descartes, France.
Abstract:
The implication of the sex-specific part of the Y-chromosome (YS-SP) on brain serotonin (5-HT) level was investigated using congenic strains for this chromosomal region. The 5-HT level, which was higher in the NZB than in the CBA/H strain of mice, was depleted by the transfer of the YS-SP from NZB on CBA/H whereas the transfer of the YS-SP from CBA/H on NZB had no effect. The variations of 5-HT levels were not correlated with plasma testosterone concentration which is also dependent of the YS-SP.
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