Rheumatologic complications of vitamin A and retinoids

Area of Science:

• Dermatology and Rheumatology
• Toxicology

Background:

• Retinoids, synthetic vitamin A derivatives, are used for skin conditions like acne and psoriasis.
• Long-term retinoid administration is associated with significant toxicity.

Purpose of the Study:

• To review the adverse rheumatologic effects of retinoid therapy.
• To highlight bone abnormalities and other musculoskeletal manifestations.

Main Methods:

• Literature review of retinoid-related adverse effects.
• Analysis of case studies describing rheumatologic manifestations.

Main Results:

• Retinoid toxicity includes bone abnormalities resembling spondyloarthropathy and diffuse idiopathic skeletal hyperostosis.
• Other reported rheumatologic issues include arthritis, myopathy, and vasculitis.

Conclusions:

• Retinoid therapy necessitates careful monitoring for potential rheumatologic adverse effects.
• Understanding these risks is crucial for managing patients on long-term retinoid treatment.