Related Experiment Video
Updated: Sep 16, 2026

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
Published on: January 25, 2017
Development and maturation of neutrophils
F M da Silva1, A M Massart-Leën, C Burvenich
1University of Gent, Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Biometrics, Belgium.
Abstract:
Inflammatory processes require the activation of immunocompetent cells. In mammals, neutrophil polymorphonuclear leukocytes (PMN) constitute one of the essential body defences against diseases. In this article knowledge of the development and maturation of neutrophils, the control of haematopoiesis and of the factors that regulate neutrophil production is reviewed. As it has recently become apparent that neutrophils can be primed by cytokines to have enhanced functional activity, the future utilization of these growth factors in bovine immunotherapy is briefly discussed.
Related Concept Videos
Lineage Commitment
Differentiation of Common Myeloid Progenitor Cells
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Production of Formed Elements
Most HSCs commit to...
Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cells of the Adaptive Immune Response

