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Related Experiment Videos

Equine strangles modelled in mice

N Chanter1, K C Smith, J A Mumford

  • 1Department of Infectious Diseases, Animal Health Trust, Newmarket, Suffolk, UK.

Veterinary Microbiology
|February 1, 1995
PubMed
Summary
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A new mouse model for strangles infection using Streptococcus equi nasal inoculation shows promising results. This model mimics key aspects of the equine disease, aiding future research into strangles pathogenesis and immunity.

Area of Science:

  • Veterinary Microbiology
  • Infectious Disease Modeling

Background:

  • Parenteral injection in mice leads to sepsis, not accurately modeling strangles.
  • A need exists for a small animal model that replicates the nasopharyngeal infection of strangles.

Purpose of the Study:

  • To develop and validate a novel mouse model of Streptococcus equi infection that mimics strangles.
  • To assess the pathological outcomes and bacterial re-isolation following intranasal S. equi challenge.

Main Methods:

  • Intranasal inoculation of 4.9 x 10^6 CFU S. equi into C3H and Balb/c mice.
  • Clinical observation (sneezing, weight gain) and histopathological analysis of nasopharyngeal tissues.
  • Bacterial re-isolation from nares of infected and control mice.

Main Results:

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  • Infected mice exhibited increased sneezing and reduced weight gain.
  • Histopathology revealed rhinitis, pharyngitis, lymphadenitis, and osteomyelitis in 22/30 mice.
  • S. equi was re-isolated from 14/22 affected mice, confirming infection.

Conclusions:

  • Nasal inoculation of S. equi in mice provides a relevant model for strangles.
  • This model facilitates further investigation into strangles pathogenesis and the development of protective immunity.