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Adult renal epithelial neoplasms
L M Weiss1, A B Gelb, L J Medeiros
1Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.
American Journal of Clinical Pathology
|May 1, 1995
Summary
This review covers adult renal epithelial neoplasms beyond renal adenocarcinoma, including oncocytoma and chromophobe carcinoma. It highlights new classifications based on cytogenetic techniques and discusses differential diagnosis and prognostic factors.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Adult renal epithelial neoplasms encompass more than just renal adenocarcinoma.
- Recent advancements in cytogenetic techniques have refined the classification of these tumors.
- Understanding these diverse neoplasms is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To review the clinical and pathologic characteristics of various adult renal epithelial neoplasms.
- To provide a basis for the differential diagnosis of these entities.
- To discuss prognostic factors specifically for renal adenocarcinoma.
Main Methods:
- Review of existing literature on renal epithelial neoplasms.
- Analysis of classical and molecular cytogenetic findings.
- Integration of clinical and pathological data.
Main Results:
- Expanded classification of adult renal epithelial neoplasms beyond renal adenocarcinoma.
- Identification of oncocytoma, chromophobe carcinoma, papillary neoplasms, collecting duct carcinoma, and neuroendocrine tumors as key entities.
- Established biologic basis for the new classification through cytogenetic studies.
Conclusions:
- The classification of adult renal epithelial neoplasms has significantly evolved.
- Cytogenetic techniques are fundamental to understanding the biology and classification of these tumors.
- Accurate differential diagnosis and understanding of prognostic factors are essential for patient management.