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Related Experiment Videos

Propofol linearly reduces the vasoconstriction and shivering thresholds

T Matsukawa1, A Kurz, D I Sessler

  • 1Thermoregulation Research Laboratory, University of California, San Francisco 94143-0648, USA.

Anesthesiology
|May 1, 1995
PubMed
Summary

This study introduces a new method to analyze thermoregulatory responses to propofol anesthesia by calculating core-temperature thresholds. Propofol significantly lowers vasoconstriction and shivering thresholds while only slightly affecting the sweating threshold.

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Area of Science:

  • Physiology
  • Anesthesiology
  • Thermoregulation

Background:

  • Thermoregulatory control involves both skin and core temperatures.
  • Maintaining constant skin temperature is crucial but challenging for evaluating warm and cold thresholds.
  • Established cutaneous contributions to sweating (10%) and vasoconstriction/shivering (20%) allow for temperature compensation.

Purpose of the Study:

  • To develop and validate a novel, minimally invasive method for determining thermoregulatory thresholds during propofol anesthesia.
  • To quantify the effects of varying propofol concentrations on sweating, vasoconstriction, and shivering thresholds.
  • To analyze propofol's impact on core-temperature thresholds by mathematically compensating for skin temperature variations.

Main Methods:

  • Five volunteers underwent four experimental days with varying propofol concentrations (0, 2, 4, 8 µg/ml).

Related Experiment Videos

  • Skin and core temperatures were manipulated to induce sweating, vasoconstriction, and shivering.
  • Mathematical compensation for skin temperature changes was applied using known cutaneous contributions to thermoregulation.

    • Main Results:

    • Propofol significantly decreased core temperatures for vasoconstriction and shivering.
    • The concentration-response slopes for vasoconstriction and shivering were similar to previous findings.
    • Increasing propofol concentration only slightly increased the sweating threshold.

    Conclusions:

    • The new method is nearly noninvasive and requires minimal core-temperature manipulation.
    • Propofol markedly reduces vasoconstriction and shivering thresholds but only slightly alters the sweating threshold.
    • The range between vasoconstriction and shivering thresholds changes minimally during propofol anesthesia.