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[Iminodimethylation, a method for pharmacomodulation in pyrimido-[3,4-a]-s-triazine series]
S Menager1, C Loire, T Petrakian
1Laboratoire de Pharmacochimie et Biopharmacie, Faculté de Médecine et de Pharmacie de Rouen, Saint-Etienne-du-Rouvray.
Annales Pharmaceutiques Francaises
|January 1, 1995
Abstract:
Primary amines react with two formaldehydes and compounds presenting two mobile hydrogen atoms, this reaction can be called iminodimethylation. This reaction can be used in order to perform a pharmacomodulation in the pyrimido [3,4-a]-s-triazine series. Against Epidermophyton floccosum, the activity is better when nitrogen 7 is not substituted, when the heroatom in position 2 is 0 instead of S and when an aromatic nucleus is directly linked to the nitrogen atom in position 3.