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Related Experiment Videos

Primary soft-tissue nocardiosis

A T Lyos1, R E Tuchler, A Malpica

  • 1Division of Plastic and Reconstructive Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

Annals of Plastic Surgery
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

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A persistent infrapatellar mass in a young man was diagnosed as Nocardia asteroides infection. Prolonged treatment with trimethoprim-sulfamethoxazole successfully resolved the Nocardia infection.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Surgical Pathology

Background:

  • Nocardia asteroides infections can present as chronic inflammatory masses.
  • Diagnosis often requires advanced microbiological and histopathological analysis.
  • Initial antibiotic treatments may be ineffective for deep-seated Nocardia infections.

Observation:

  • A 20-year-old man had a 4.5-year history of a left infrapatellar mass with draining sinuses.
  • Previous antibiotic courses failed to resolve the lesion.
  • Biopsies showed nonspecific inflammation, delaying diagnosis.

Findings:

  • Surgical resection revealed an inflammatory mass with abscesses.
  • Intraoperative cultures confirmed Nocardia asteroides as the causative agent.

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  • Microscopic examination of biopsies showed nonspecific acute and chronic inflammation.

    • Implications:

    • Nocardia asteroides should be considered in chronic, non-healing inflammatory masses, especially with sinus tracts.
    • Prompt microbiological identification is crucial for effective treatment.
    • Successful management involves prolonged antibiotic therapy, often with trimethoprim-sulfamethoxazole.