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Urinary tract infection: a comparison of four methods of investigation
J M Smellie1, S P Rigden, N P Prescod
1Department of Paediatrics, University College Hospital, London.
Insights
Ultrasonography is unreliable for diagnosing urinary tract infections (UTI) in children. It often misses key indicators like vesicoureteric reflux and renal scarring, making it inadequate as a standalone diagnostic tool.
Area of Science:
- Pediatric Nephrology
- Diagnostic Imaging
- Urology
Background:
- Investigating pediatric urinary tract infections (UTI) requires optimal diagnostic strategies.
- Current imaging modalities for pediatric UTI assessment lack definitive comparative analysis.
Purpose of the Study:
- To compare the diagnostic efficacy of ultrasonography (US), contrast micturating cystourethrography (MCU), intravenous urography (IVU), and technetium-99m dimercaptosuccinic acid (DMSA) in children with UTI.
- To determine the reliability of ultrasonography in detecting vesicoureteric reflux (VUR) and renal scarring in pediatric UTI cases.
Main Methods:
- A comparative study involving 58 children under 14 years with UTI.
- Utilized ultrasonography, MCU, IVU, and DMSA studies for investigation.
- Compared results across all four imaging modalities.
Main Results:
- Ultrasonography showed significant disparities compared to MCU, IVU, and DMSA.
- Ultrasonography failed to detect VUR in 36 children diagnosed by MCU.
- Radiological renal scarring was missed or inaccurately reported by ultrasonography in multiple cases.
- Duplex kidneys identified by IVU were not recognized by ultrasonography or DMSA.
Conclusions:
- Ultrasonography alone is inadequate for the comprehensive investigation of pediatric UTI.
- Ultrasonography demonstrates unreliability in detecting VUR, renal scarring, and inflammatory changes.
- Integrated use of multiple imaging modalities is crucial for accurate pediatric UTI diagnosis.
Abstract:
The optimal regimen for investigating children with urinary tract infection (UTI) remains uncertain. Ultrasonography, contrast micturating cystourethrography (MCU), intravenous urography (IVU), and technetium-99m dimercaptosuccinic acid (DMSA) studies were performed in 58 children with UTI under 14 years of age attending two teaching hospitals and the results compared. All four investigations were normal in 12 children. In 36 with vesicoureteric reflux (VUR) on MCU, dilatation was reported on ultrasonography in eight children. Radiological renal scarring was seen in 20 children; it was suspected on ultrasonography in nine, with dilatation alone in four, and a normal report in seven. Duplex kidneys identified on IVU were unrecognised on ultrasonography or DMSA studies; ultrasonography showed no change corresponding to presumed acute defects on DMSA studies that later resolved. Disparities were observed at all ages. This study suggests that ultrasonography is unreliable in detecting VUR, renal scarring, or inflammatory change and, alone, is inadequate for investigating UTI in children.
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