Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated metabolic rates in obesity

W P James, H L Davies, J Bailes

    Lancet (London, England)
    |May 27, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reproducibility of 'COST reference microplasma jets'.

    Plasma sources science & technology·2021
    Same author

    Twofold improved tumor-to-brain contrast using a novel T1 relaxation-enhanced steady-state (T<sub>1</sub>RESS) MRI technique.

    Science advances·2020
    Same author

    A call to arms: the need to create an inter-institutional concussion neuroimaging consortium to discover clinically relevant diagnostic biomarkers and develop evidence-based interventions to facilitate recovery.

    Developmental neuropsychology·2015
    Same author

    Nutrition, the brain and cognitive decline: insights from epigenetics.

    European journal of clinical nutrition·2014
    Same author

    The global epidemic of obesity.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Obesity: translating scientific research into therapeutic and preventive benefit.

    The International journal of risk & safety in medicine·2013

    Obese individuals have higher resting metabolic rates (R.M.R.s) due to increased lean body mass, not excess fat. This elevated R.M.R. decreases during weight loss, necessitating sustained dietary changes for weight management.

    Area of Science:

    • Metabolism and Obesity Research
    • Human Physiology

    Background:

    • Obesity is a complex metabolic condition.
    • Resting metabolic rate (R.M.R.) is a key factor in energy balance.

    Purpose of the Study:

    • To investigate the relationship between obesity, lean body mass, and resting metabolic rates.
    • To understand R.M.R. changes during weight stability and weight loss in obese individuals.

    Main Methods:

    • Measured resting metabolic rates (R.M.R.s) in 69 obese patients during weight stability.
    • Assessed R.M.R. changes in 30 patients during weight loss.
    • Analyzed R.M.R. in relation to lean body mass and body fat.

    Main Results:

    • Obese patients exhibited higher R.M.R.s (megajoules per 24 hours) than normal-weight subjects, an effect masked by traditional surface area normalization.

    Related Experiment Videos

  • Increased R.M.R. was correlated with a significant rise in lean body mass (36% in men, 32% in women), not excess fat.
  • R.M.R. declined progressively during weight loss.

    • Conclusions:

    • Elevated R.M.R. in obesity is a compensatory mechanism for energy balance, driven by increased lean body mass.
    • The fall in R.M.R. during slimming highlights the necessity of permanent dietary reduction to maintain energy balance post-weight loss.
    • R.M.R. measurement alone in the obese state is insufficient for understanding obesity's pathogenesis.