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Related Experiment Videos

Enterococcus faecium and Enterococcus faecalis bacteremia: acquisition and outcome

G A Noskin1, L R Peterson, J R Warren

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 1, 1995
PubMed
Summary
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Enterococcus faecium bacteremia is rising and primarily affects severely ill patients. This infection is linked to higher mortality rates compared to Enterococcus faecalis bacteremia.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Increasing incidence of enterococcal bacteremia, particularly due to Enterococcus faecium.
  • Need to understand the clinical significance and outcomes of E. faecium bacteremia.

Purpose of the Study:

  • To compare the clinical characteristics and outcomes of patients with E. faecium bacteremia versus E. faecalis bacteremia.
  • To identify risk factors associated with E. faecium bacteremia.

Main Methods:

  • Retrospective comparison of 16 patients with E. faecium bacteremia and 56 patients with E. faecalis bacteremia.
  • Analysis of patient demographics, clinical presentation, risk factors, and mortality.

Main Results:

Related Experiment Videos

  • E. faecium bacteremia occurred in more severely ill patients with organ dysfunction.
  • Nosocomial acquisition, cancer, neutropenia, renal insufficiency, corticosteroid use, and prior broad-spectrum antibiotics were associated with E. faecium.
  • Mortality was significantly higher in E. faecium bacteremia (50%) compared to E. faecalis (11%).

    • Conclusions:

    • Enterococcus faecium frequently infects debilitated patients.
    • E. faecium bacteremia is a significant contributor to mortality, especially in specific patient subgroups.
    • E. faecium represents a more virulent pathogen in the context of bacteremia compared to E. faecalis.