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Related Experiment Videos

Articular aspergillosis: case report

L Alvarez1, E Calvo, C Abril

  • 1Orthopedics Department, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 1, 1995
PubMed
Summary
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A rare Aspergillus fumigatus infection caused tibia osteomyelitis and knee septic arthritis in a renal transplant patient. Initial synovial fluid analysis showed pyrophosphate crystals, not bacteria.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Renal transplant recipients are immunocompromised, increasing susceptibility to opportunistic infections.
  • Aspergillus fumigatus is an opportunistic mold that can cause invasive disease in immunocompromised individuals.
  • Septic arthritis and osteomyelitis are serious joint and bone infections, respectively.

Observation:

  • A renal transplant recipient presented with tibia osteomyelitis and knee septic arthritis.
  • The joint fluid, while indicative of infection, was initially sterile.
  • Pyrophosphate crystals were notably abundant in the synovial fluid.

Findings:

  • The causative agent was identified as Aspergillus fumigatus, an unusual pathogen for this presentation.

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  • The sterile initial synovial fluid contrasted with the clinical signs of septic arthritis.
  • The presence of pyrophosphate crystals may have complicated the initial diagnosis.
  • Implications:

    • Highlights the importance of considering fungal pathogens, particularly Aspergillus, in immunocompromised patients with joint infections.
    • Underscores the need for advanced diagnostic techniques when initial cultures are negative.
    • Suggests that pyrophosphate crystal arthropathy might coexist with or mimic infectious arthritis in specific patient populations.