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Cancer, immune function, and physical activity

R J Shephard1, P N Shek

  • 1School of Physical & Health Education, Univ. of Toronto, Ont.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|March 1, 1995
PubMed
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Regular physical activity may lower cancer risk, especially for colon and reproductive tumors. Exercise may also improve early-stage cancer outcomes by modulating immune function, though more research is needed.

Area of Science:

  • Oncology
  • Immunology
  • Exercise Science

Background:

  • Epidemiological studies suggest a link between physical activity and reduced neoplasm risk.
  • Certain tumors, including colon and female reproductive tract cancers, appear particularly affected.
  • Exercise may influence the clinical course of cancer, especially in early stages.

Purpose of the Study:

  • To review the evidence for physical activity's protective effects against cancer.
  • To explore the potential immuno-modulatory mechanisms underlying exercise's anti-cancer effects.
  • To identify areas for future research in exercise oncology.

Main Methods:

  • Review of epidemiological studies and animal models.
  • Analysis of exercise-induced changes in immune cell activity (macrophages, NK cells, LAK cells, neutrophils).

Related Experiment Videos

  • Examination of exercise's impact on cytokine regulation.

    • Main Results:

    • Moderate habitual physical activity shows protective associations with certain neoplasms.
    • Exercise influences the activity of various immune cells and cytokines.
    • Immuno-modulation is a potential mechanism for exercise's protective effects.

    Conclusions:

    • Physical activity may offer protection against specific cancers.
    • Immune system modulation by exercise could play a role in cancer prevention and management.
    • Further research is required to confirm the direct impact of exercise-induced immune changes on cancer risk.