Related Experiment Videos
Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis
S Fekrat1, J A Haller, W R Green
1Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-9248, USA.
Cornea
|March 1, 1995
Summary
A rare case of Candida parapsilosis endophthalmitis led to keratitis after cataract surgery. The fungus persisted in the cornea, causing recurrent infections despite extensive treatment.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Phacoemulsification with intraocular lens implantation is a common cataract surgery.
- Endophthalmitis is a serious intraocular infection that can occur post-surgery.
- Candida parapsilosis is an opportunistic fungal pathogen.
Observation:
- A patient developed Candida parapsilosis endophthalmitis and subsequent keratitis after cataract surgery.
- Recurrent infections occurred over two years despite aggressive medical and surgical interventions.
- A fungal plaque formed on the corneal endothelium, acting as a sanctuary site.
Findings:
- Aggressive treatment with antifungal medications (amphotericin B, fluconazole) and surgical interventions were employed.
- The fungal plaque on the corneal endothelium contributed to persistent and recurrent inflammation.
- Cultures confirmed Candida parapsilosis in the plaque and capsular remnants.
Implications:
- This case highlights the potential for fungal sanctuary sites in the posterior cornea after intraocular surgery.
- Recurrent Candida endophthalmitis requires persistent and multifaceted management strategies.
- Understanding fungal behavior in the post-surgical eye is crucial for preventing vision loss.