The effect of fibronectin on re-epithelialization of rabbits cornea after alkali burn

The authors found experimentally that (1) fibronectin enhanced the healing of rabbit corneal epithelium after alkali burn and prevented the secondary breakdown; (2) it rapidly deposited on the denuded basement membrane to disappear as epithelial cells slid over, and (3) ultrastructurally, the neighbouring epithelial cells became flattened, with filopodia at the advancing edge, and extended to the wounded areas at 24 hours after the burn. However, the epithelial defects recurred 72 hours after the burn when the basement membrane vanished till after the 8th week, indicating that the latter was associated with the secondary epithelial breakdown.