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Old phage, new insights: two recently recognized mechanisms of transcriptional regulation in bacteriophage T4
E N Brody1, G A Kassavetis, M Ouhammouch
1Department of Biological Sciences, State University of New York, Buffalo 14260-1300, USA.
FEMS Microbiology Letters
|April 15, 1995
Abstract:
The regulation of bacteriophage T4 middle and late gene expression involves previously unrecognized mechanisms. Middle transcription requires a DNA-binding transcriptional activator and a sigma 70-binding co-activator. The coupling of late transcription to DNA replication is effected by a DNA-tracking protein that is loaded onto DNA by an assembly factor at enhancer-like entry sites. Late transcription also requires an RNA polymerase core-binding co-activator. The co-activators of T4 middle and late transcription share the property of depressing unactivated, basal transcription.