Related Experiment Video
Updated: Aug 8, 2026

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
[Activation-dependent expression of Fc gamma-receptors on glomerular mesangial cells]
J E Gessner1, H H Radeke, P Uciechowski
1Abteilungen Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
Abstract:
Resting, non-cycling mesangial cells (MCs) can be induced by IFN gamma to express the Fc gamma-RIIIa and Fc epsilon RI-gamma subunits of the CD16TM receptor complex. After cell surface expression of CD16TM by IFN gamma induction the binding of immune complexes to MCs induces IL-6 secretion. A Fc epsilon RI-gamma gene knockout has recently been described. It is now possible to study the function of Fc gamma RIIIa and other gamma chain associated Fc receptors in the initiation and progression of chronic glomerular inflammation in the context of the intact immune system in vivo.
Related Concept Videos
Amplifying Signals via Enzymatic Cascade
TGF - β Signaling Pathway
Activation and Inactivation of G Proteins
cAMP-dependent Protein Kinase Pathways
Intracellular Signaling Affects Focal Adhesions
Some...
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

