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Related Experiment Videos

Brainstem lesions and click lateralization in patients with multiple sclerosis

M Furst1, R A Levine, A D Korczyn

  • 1Department of Electrical Engineering-Systems, Faculty of Engineering, Tel Aviv University, Israel.

Hearing Research
|January 1, 1995
PubMed
Summary

Multiple sclerosis (MS) can impair auditory processing. Lesions in the brainstem

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Clinical Neurology

Background:

  • Auditory lateralization relies on precise processing of interaural time differences (ITD) and interaural level differences (ILD).
  • Multiple sclerosis (MS) can affect the central auditory pathways, potentially impacting sound localization abilities.
  • Understanding the relationship between MS lesions and auditory deficits is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the effects of brainstem lesions in multiple sclerosis (MS) patients on the ability to lateralize dichotic sounds using interaural time delays (ITD) and interaural level differences (ILD).
  • To correlate specific lesion locations within the auditory pathway with deficits in auditory lateralization.

Main Methods:

  • Psychoacoustical testing of dichotic click lateralization using ITD and ILD in seven MS subjects with normal audiograms.

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  • Magnetic resonance imaging (MRI) of the brainstem to identify and localize MS lesions.
  • Matching MRI scans with a computerized brainstem atlas to determine affected auditory pathway structures.

    • Main Results:

    • Two MS subjects with no auditory pathway lesions performed normally on both ITD and ILD tasks.
    • Two MS subjects with trapezoid body lesions lateralized sounds normally with ILD but not ITD.
    • Three MS subjects with unilateral lateral lemniscus lesions failed to lateralize sounds using either ITD or ILD.

    Conclusions:

    • Auditory lateralization deficits in MS patients are associated with specific brainstem lesion locations.
    • Lesions in the trapezoid body may selectively impair ITD processing.
    • Unilateral lesions of the lateral lemniscus appear to disrupt both ITD and ILD processing, suggesting a critical role in binaural hearing.