Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

E-cadherin expression in intestinal epithelium

A Doğan1, Z D Wang, J Spencer

  • 1Department of Histopathology, University College, London Medical School.

Journal of Clinical Pathology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of beta-glucan on oxidative stress, inflammation, hormonal and histopathological changes in dehydroepiandrosterone-induced polycystic ovary syndrome.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2025
Same author

Determination of periodic deformation from InSAR results using the FFT time series analysis method in Gediz Graben.

Natural hazards (Dordrecht, Netherlands)·2023
Same author

Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-arm, multicenter trial.

Trials·2022
Same author

Effect of Helicobacter pylori infection on the first-line treatment outcomes in patients with immune thrombocytopenic purpura.

European review for medical and pharmacological sciences·2022
Same author

Preoperative and postoperative ultrasound elastography findings of the sciatic nerve in patients with unilateral lumbar foraminal disc herniation: a pre-test and post-test design.

European review for medical and pharmacological sciences·2022
Same author

The clinicopathological features and survival of Castleman disease: a multicenter Turkish study.

European review for medical and pharmacological sciences·2022
Same journal

Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

Journal of clinical pathology·2026
Same journal

MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

Journal of clinical pathology·2026
Same journal

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same journal

MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

Journal of clinical pathology·2026
Same journal

Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

Journal of clinical pathology·2026
Same journal

Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

Journal of clinical pathology·2026
See all related articles

E-cadherin is generally stable in the intestine, but expression decreases near ulcers to aid regeneration. In fetal gut cultures, T cell activation lowered E-cadherin, while HT29 cells showed increased expression with specific treatments.

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Immunology

Background:

  • E-cadherin is a crucial cell adhesion molecule in epithelial tissues.
  • Its role in intestinal inflammation and regeneration is not fully understood.

Purpose of the Study:

  • To investigate E-cadherin expression in normal and inflamed intestines.
  • To examine E-cadherin in a colonic cell line, fetal intestine, and a T cell-mediated enteropathy model.
  • To determine if intestinal inflammation alters E-cadherin expression.

Main Methods:

  • Immunohistochemistry was used to assess E-cadherin.
  • Tissues examined included normal/inflamed intestine, HT29 cells, fetal intestine, and fetal gut organ cultures.
  • Enteropathy was induced in fetal gut cultures via T cell activation.

Related Experiment Videos

Main Results:

  • E-cadherin showed strong, even epithelial expression in most intestinal samples.
  • Reduced E-cadherin was observed in "ulcer associated cell lineage" in Crohn's disease.
  • Fetal gut cultures with activated T cells had lower epithelial E-cadherin.
  • HT29 cells exhibited increased E-cadherin after treatment with activated tonsil cell conditioned medium.

Conclusions:

  • E-cadherin is generally consistently expressed in the intestinal epithelium, even during inflammation.
  • Reduced E-cadherin near ulcers may facilitate tissue regeneration.
  • Modulation of E-cadherin by cytokines and T cell activation suggests a dynamic role in intestinal health and disease.