The in vitro effect of sodium mercaptoundecahydrododecaborate (borocaptate) on sulfhydryl groups of different rat tissues
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E Buchar1, V Horn, L Kameníková
1Institute of Pharmacology, Czech Academy of Sciences, Prague.
Methods and Findings in Experimental and Clinical Pharmacology
|November 1, 1994
Abstract:
The effect of borocaptate on structural protein sulfhydryl (SH) groups of different organs and kidney subcellular fractions was studied in vitro. It was shown that the binding capacity of borocaptate is not the same for different tissues and subcellular fractions. The highest binding capacity was in the liver, while kidney and brain values were significantly lower. Therefore, it appears that the same concentration of borocaptate may have different effects in various organs.