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Apolipoprotein E type epsilon 4 allele frequency is not increased in patients with sporadic inclusion-body myositis
C R Harrington1, J R Anderson, K K Chan
1Cambridge Brain Bank Laboratory, Department of Psychiatry, University of Cambridge Clinical School, UK.
Abstract:
The apolipoprotein E genotype was determined for 11 patients with sporadic inclusion-body myositis. Seven cases had the genotype epsilon 3/epsilon 3, the other four cases, epsilon 3/epsilon 4. The frequency of the epsilon 4 allele in this group of patients (0.182) was not significantly increased compared with elderly controls (0.147; n = 58), in contrast to Alzheimer's disease in which there was a significant increase (0.328; n = 67). The epsilon 2 allele was not found in any of the 11 sporadic inclusion-body myositis patients and its frequency was decreased in Alzheimer's disease. Despite certain pathological similarities that exist between inclusion body myositis and Alzheimer's disease, their association with particular apolipoprotein E genotypes is distinct.