Related Experiment Videos
Carbamazepine-induced changes in plasma levels of neuroleptics
J Tiihonen1, H Vartiainen, P Hakola
1Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland.
Pharmacopsychiatry
|January 1, 1995
Abstract:
We compared the effect of carbamazepine and oxcarbazepine treatment on the plasma levels of clozapine and thioridazine in 12 patients. There was a 47% decrease in the plasma levels of clozapine (p < 0.005, Students two-tailed t-test) during carbamazepine treatment, while the effects on the thioridazine levels were less marked (n.s.). Since carbamazepine is also used in patients receiving concurrent clozapine therapy, it is important to take this marked interaction between these two drugs into account.