Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rheumatoid factor production in the joint

F C Breedveld1, H G Otten, M R Daha

  • 1Department of Rheumatology, University Hospital, Leiden, The Netherlands.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preface.

Seminars in arthritis and rheumatism·2019
Same author

Advances in targeted therapies 2017.

Clinical immunology (Orlando, Fla.)·2018
Same author

Advances in targeted therapies XIII.

Annals of the rheumatic diseases·2012
Same author

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2011.

Annals of the rheumatic diseases·2012
Same author

European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies.

Annals of the rheumatic diseases·2011
Same author

Advances in targeted therapies XII. Preface.

Annals of the rheumatic diseases·2011

Rheumatoid arthritis patients' bone marrow cells produce rheumatoid factor (RF), suggesting the bone marrow is the primary source of circulating RF in RA. This finding impacts understanding of autoimmune disease origins.

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
  • Rheumatoid factor (RF) is a key autoantibody implicated in RA pathogenesis.
  • The primary origin of circulating RF in RA patients remains incompletely understood.

Purpose of the Study:

  • To investigate the cellular origin of circulating rheumatoid factor (RF) in patients with rheumatoid arthritis (RA).
  • To compare the RF-producing capacity of mononuclear cells from different anatomical sites in RA patients.

Main Methods:

  • Isolation of mononuclear cells from bone marrow, synovium, and peripheral blood of RA patients.
  • In vitro culture of isolated mononuclear cells to assess immunoglobulin production.

Related Experiment Videos

  • Quantification of IgG-, IgA-, and IgM-RF production by these cells.

    • Main Results:

    • Mononuclear cells from bone marrow demonstrated the capacity to produce IgG-, IgA-, and IgM-RF.
    • The levels of RF produced by bone marrow cells were comparable to those produced by synovial cells.
    • Peripheral blood mononuclear cells also showed RF production, but the study focused on bone marrow and synovium origins.

    Conclusions:

    • Bone marrow mononuclear cells are a significant source of RF production in RA patients.
    • The findings suggest that the bone marrow is the predominant origin of circulating RF in RA.
    • This implicates bone marrow in the autoimmune processes driving rheumatoid arthritis.