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[Mumps vaccines: vaccination failures from an immunological viewpoint]
1Bundesamt für Gesundheitswesen, Bern.
Sozial- Und Praventivmedizin
|January 1, 1995
Summary
Different vaccines, like oral Poliovirus (Sabin) and inactivated Poliovirus (Salk), highlight mucosal and systemic immunity. Vaccinated individuals may experience subclinical infections, indicating potential vaccine failures even with protective systemic immunity.
Area of Science:
- Immunology
- Vaccinology
Context:
- Comparing mucosal and systemic immunity using Poliovirus vaccines (Sabin and Salk).
- Observing subclinical reinfections in measles and rubella outbreaks among vaccinated populations.
Purpose:
- To illustrate the distinct roles of mucosal and systemic immunity in vaccine response.
- To analyze vaccine failures in the context of differing immune responses.
Summary:
- Subclinical reinfections are more common than clinical disease in vaccinated individuals, as seen in measles and rubella outbreaks.
- Mumps cases in vaccinated Swiss pupils suggest secondary mucosal vaccine failures despite intact systemic immunity.
Impact:
- Findings inform vaccination policy and vaccine handling strategies.
- Highlights the importance of considering mucosal immunity in vaccine efficacy.