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[Anti-melanoma immunoscintigraphy]

A I Santos¹, F Godinho

¹Instituto de Medicina Nuclear, Faculdade de Medicina de Lisboa, Hospital de Santa Maria.

Acta Medica Portuguesa

|January 1, 1995

Summary

Immunoscintigraphy using antibody 225.28S shows high accuracy in detecting melanoma. This nuclear medicine technique aids in diagnosing skin and uveal melanoma metastases and primary lesions.

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Area of Science:

Nuclear Medicine
Oncology
Immunology

Background:

Nuclear Medicine aids oncologic disease study.
Immunoscintigraphy evaluates biodistribution of radiolabeled antibodies against tumor antigens.
First used for skin malignant melanoma in 1983.

Purpose of the Study:

Evaluate the clinical utility of immunoscintigraphy in diagnosing skin and uveal melanoma.
Assess the accuracy of immunoscintigraphy in detecting melanoma metastases and primary lesions.

Main Methods:

Utilized antibody 225.28S (IgG2a) targeting a melanoma antigen.
Performed 67 immunoscintigraphy exams between 1992-1994 (44 skin, 23 uveal melanoma).
Calculated true positive and true negative rates for both melanoma types.

Main Results:

Achieved 87.5% true positive and 90% true negative rates for skin melanoma.
Achieved 94% true positive and 83% true negative rates for uveal melanoma.
Demonstrated effectiveness in detecting loco-regional and distant skin melanoma metastases and aiding differential diagnosis.

Conclusions:

Immunoscintigraphy is valuable for staging skin melanoma, identifying unsuspected metastases, and differential diagnosis.
Immunoscintigraphy may assist in evaluating primary uveal melanoma and differentiating it from other intra-ocular lesions.

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