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Premature centromere division: a possible manifestation of chromosome instability
1Department of Pediatrics, University Medical School, Pécs, Hungary.
American Journal of Medical Genetics
|March 13, 1995
Abstract:
Retrospective analysis of "routine" chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia-teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.