Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Middle ear gas composition and middle ear aeration

J Sadé1, M Luntz, D Levy

  • 1Ear Research Laboratory, Sackler School of Medicine, Tel-Aviv University, Israel.

The Annals of Otology, Rhinology, and Laryngology
|May 1, 1995
PubMed
Summary

Gas composition in guinea pig middle ears resembles venous blood, not air. Diffusion between the middle ear and blood likely controls gas content, potentially explaining negative middle ear pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rates of progression to hypertension among non-hypertensive subjects: implications for blood pressure screening.

European heart journal·2002
Same author

Genome scan for quantity of hand osteoarthritis: the Framingham Study.

Arthritis and rheumatism·2002
Same author

Risk factors in HIV-associated diarrhoeal disease: the role of drinking water, medication and immune status.

Epidemiology and infection·2002
Same author

Impact of high-normal blood pressure on the risk of cardiovascular disease.

The New England journal of medicine·2002
Same author

Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors.

The Journal of physiology·2002
Same author

Autologous endometrial coculture in patients with in vitro-fertilization (IVF) failure: correlations of outcome with leukemia inhibiting factor (LIF) production.

American journal of reproductive immunology (New York, N.Y. : 1989)·2002

Area of Science:

  • Otolaryngology
  • Physiology
  • Biomedical Engineering

Background:

  • The gas composition of the middle ear is not well understood.
  • Previous studies suggest differences from atmospheric air.

Purpose of the Study:

  • To measure gas partial pressures in the guinea pig middle ear.
  • To investigate the role of diffusion in middle ear gas regulation.

Main Methods:

  • Continuous on-line measurement of gas partial pressures using a mass spectrometer.
  • Study conducted on 14 guinea pigs.

Main Results:

  • Average middle ear gas values: CO2 67.55 mm Hg, O2 48.91 mm Hg, N2 596.54 mm Hg.
  • Middle ear gas composition significantly differs from air and resembles venous blood.
  • Findings support bilateral diffusion between middle ear and blood.

Conclusions:

  • Gas content of the middle ear is regulated by diffusion under both physiologic and pathologic conditions.
  • Excessive diffusion may lead to negative middle ear pressure.
  • Poor mastoid pneumatization may impair pressure regulation.

Related Experiment Videos