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Intraosseous lipoma. A report of three cases
G Liapi-Avgeri1, P Markakis, H Kokka
1Department of Pathology, General Hospital Amalia Fremming, Athens, Greece.
Summary
Intraosseous lipomas, rare benign bone tumors, can be misdiagnosed due to evolving features. Accurate diagnosis of these bone lesions requires correlating clinical, radiographic, and microscopic findings.
Area of Science:
- Orthopedic Oncology
- Skeletal Radiology
- Bone Pathology
Background:
- Intraosseous lipomas are exceptionally rare primary benign bone tumors.
- Their presentation can mimic other bone lesions, leading to diagnostic challenges.
- Evolutionary changes and limited clinical data often complicate interpretation.
Observation:
- Three male patients (ages 23, 34, 35) presented with intraosseous lipomas.
- Affected bones included the tibia (two cases) and calcaneus (one case).
- Histologically, all tumors demonstrated mature adipose tissue.
Findings:
- The histologic pattern confirmed mature adipose tissue in all cases.
- Diagnosis relied on integrating clinical presentation, radiographic imaging, and light microscopy.
- Correlation of findings is crucial for accurate intraosseous lipoma diagnosis.
Implications:
- Highlights the importance of multidisciplinary correlation in diagnosing rare bone tumors.
- Emphasizes the need for careful evaluation of radiographic and clinical data alongside histology.
- Contributes to understanding the diagnostic nuances of intraosseous lipomas.

